Histopathology

Anatomical pathology is the major endpoint to toxicology studies. Potential target organ toxicity of pharmaceuticals has to be assessed with accuracy to provide support for human clinical trials.

Vivotecnia‘s commitment to highest quality and scientific standards has led us to partner with Anapath Services, a world leader laboratory in anatomical pathology, a team of scientists internationally recognized which combines not only the toxicological pathology but also neuropathology, inhalation pathology and bone marrow evaluations, among others.

Anapath is experienced, knowledgeable, and ready to meet your needs, by providing:

Routine Histology:

  • Necropsy (at client facility)
  • Histotechnique
  • Histopathology Evaluation

Special Techniques:

  • Special stains (e.g. PAS, Pearls, Masson Trichrom, Bodian)
  • Plastic embedding of hard tissue (not decalcified) or implants
  • Plastic embedding for neurotoxicity studies
  • Frozen sectioning
  • Bone Marrow Differentiation (at least 500 cells or populations)
  • Quantitative Ovary count according to Peters and Pederson
  • Qualitative and Quantitative Sperm staging
  • Immunohistochemistry and In-Situ Hybridization
  • Ultrastructure
  • Fluorescence Microscopy, Digital Microscopy, Laser Digital Microscopy, Hyper-Spectral Microscopy (CytoViva)
  • Confocal Microscopy, Electron Microscopy (Scanning includes EDX, TEM), High Resolution Micro-CT (all in collaboration with our partners)
  • Image Analysis
  • Image Analysis Report
  • Special species (e.g. fish, amphibian, birds, invertebrate)
  • Reprotoxicology/Fetal pathology:
    – Fresh Visceral, Microdissection, Wilson technique
    – Skeletal examination of stained fetuses

Toxicological/Experimental Pathology:

  • Consultation on complete study designs
  • Consultation on specific histological or histopathological problems
  • Preparation of documentations for authorities
  • Elaboration of documents for partnerships in development
  • Risk analysis
  • Organization and control of histotechnique including all possible special techniques
  • Organization and performance of peer reviews and pathology working groups
  • Conventional tissue evaluation and reporting
  • For evaluations on special fields consult our member list

Additional Services:

  • Organization of archiving on request
  • Individual consultation on histological questions

Anatomy / Necropsy / Histotechnique / Histopathology:

  • Consulting and professional training

Our alliance with Anapath guarantees the highest quality in anatomical pathology

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