Inhalation Team
Our inhalation team consists of a highly qualified senior study director and technicians with wide expertise in the following areas:
- Exposure system set-up
- Test atmosphere characterization: test concentration and particle size distribution
- Atmospheric monitoring: air flow rate, temperature, relative humidity, oxygen and CO2
- Aerosol generation for solid, liquid and vapor products
- Smoke aerosol generation using several types of smoking machines: ISO or Health Canada intense regimes
- Detailed clinical observations in rodents based on respiratory pattern or behavior and postural changes, altered response to handling or presence of abnormal movements
- Collection and analysis of bronchoalveolar lavage fluid (BALF)
HISTOPATHOLOGY OF RESPIRATORY TRACT ORGANS
| ORGAN | SECTION |
|---|---|
| Nose (four transverse sections) | -immediately posterior to the upper incisor teeth -posterior to incisive papilla -at second palatal ridge between first and second molar teeth |
| Larynx (four transverse sections) | -at mid base of epiglottis level 0 (below) -at distal base of epiglottis level 1 (below) -at arytenoids projections level 2 (below) -at vocal folds level 4 (below) |
| Trachea (one longitudinal section) | at bifurcation |
| Lungs (one longitudinal section) | all lobes |
- In situ plethysmography during exposure
- Analytical and bioanalytical determination with HPLC and gas chromatography
- Blood carboxyhemoglobin determination
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