Toxicology on Biocidal Products
Vivotecnia offers a wide range of toxicology tests on biocidal products and active substances to help our clients obtain the product marketing authorization in full compliance with the biocidal products regulation (BPR, Regulation (EU) 528/2012).
Vivotecnia offers in vivo acute toxicology tests on biocidal products combined with in vitro toxicology studies in order to meet regulatory requirements for acute toxicity testing.
Oral toxicity
- Acute oral toxicity -fixed-dose procedure, OECD 420
- Acute oral toxicity – acute toxic class method, OECD 423
- Acute oral toxicity: up-and-down procedure, OECD 425
Dermal toxicity
Inhalation toxicity
Skin irritation/corrosion
- Acute dermal irritation/corrosion, OECD 404
- In vitro skin corrosion: human skin model test, OECD 431
- In vitro skin irritation: reconstructed human epidermis test method, OECD 439
Eye irritation/corrosion
- Acute eye irritation/corrosion, OECD 405
- Bovine corneal opacity and permeability test method for identifying i) chemicals inducing serious eye damage, and ii) chemicals not requiring classification for eye irritation or serious eye damage, OECD 437
Skin sensitization
- Skin sensitization (Magnusson and Kligman guinea pig maximization test / Buehler test), OECD 406
- Skin sensitization – local lymph node assay, OECD 429
- In vitro skin irritation: reconstructed human epidermis test method, OECD 439
- In vitro skin sensitization: ARE-Nrf2 luciferase test method, OECD 442D
Rodent administration routes
- Chronic toxicity study (rodents, 12 months), OECD 452
- Combined chronic toxicity/carcinogenicity studies, OECD 453
- Inhalation
- Dermal
- Gavage
- Dietary
Study lengths
- 28 and 90 days
- 12, 18 and 24 months
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Experience
Vivotecnia’s BPR testing services feature programs tailored to facilitate successful registration of your product.
Vivotecnia partners with a large and experienced worldwide community to achieve full BPR compliance within the EU and compliance with analogous regulations further abroad.
BPR MILESTONES:
- Chemical safety testing services
- Global regulatory submissions
- Transparency with authorities, downstream industry and consumers
- Customer business information protection
- Inhalation testing