local tolerance for chemicals

Local Tolerance for chemicals

Vivotecnia offers global REACH expertise and full toxicology portfolio to support Safety Testing of Chemicals according to information requirements detailed in Annex VII-X of the REACH directive for skin and eye irritation and skin sensitization testing. We can perform these tests as stand-alone studies or as a part of a “Six-pack” for acute toxicity testing:

 

  • Skin irritation / corrosion (in vitro / in vivo)
  • Eye irritation / corrosion (in vitro / in vivo)
  • Sensitization (in vitro / in vivo)
  • Oral toxicity (OECD 423, 425 and 420)
  • Dermal toxicity (OECD 402)
  • Inhalation acute toxicity (OECD 403 and 436)
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Methodology
  • REACH regulation (Regulation (EC) No 1907/2006.
  • Directive 67/548/EEC and Regulation (EC) No. 1272/2008 on the classification, labeling and packaging (CLP) of substances and mixtures
  • The Globally Harmonized System of Classification and Labeling of Chemicals (GHS)

 

Test Methods

  • OECD Test No. 431: In Vitro Skin Corrosion: Human Skin Model Test
  • OECD Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method
  • OECD Test No. 404: Acute Dermal Irritation/Corrosion (In vivo)
  • OECD Test No. 406: Skin Sensitisation (Guinea Pig Maximisation Test of Magnusson and Kligman / Buehler Test)
  • OECD Test No. 429: Skin Sensitisation Local Lymph Node Assay
  • OECD Test No. 442A: Skin Sensitisation Local Lymph Node Assay: DA
  • OECD Test No. 442B: Skin Sensitization Local Lymph Node Assay: BrdU-ELISA
  • OECD Test No. 442C: In Chemico Skin Sensitisation Direct Peptide Reactivity Assay (DPRA)
  • OECD Test No. 442D: In Vitro Skin Sensitisation ARE-Nrf2 Luciferase Test Method

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