local tolerance for chemicals

Local Tolerance for chemicals

Vivotecnia offers global REACH expertise and a comprehensive toxicology testing portfolio to support safety testing of chemicals according to information requirements detailed in annexes VII-X of the REACH directive for skin and eye irritation and skin sensitization testing. We can perform these tests for local tolerance for chemicals as stand-alone studies or as a part of an acute toxicity testing “six-pack”:


  • Skin irritation / corrosion (in vitro / in vivo)
  • Eye irritation / corrosion (in vitro / in vivo)
  • Sensitization (in vitro / in vivo)
  • Oral toxicity (OECD 423, 425, 420)
  • Dermal toxicity (OECD 402)
  • Acute inhalation toxicity (OECD 403, 436)
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  • REACH regulation (EC) No 1907/2006
  • Directive 67/548/EEC and Regulation (EC) No 1272/2008 on the classification, labeling and packaging (CLP) of substances and mixtures
  • Globally Harmonized System of Classification and Labeling of Chemicals (GHS)

Test Methods


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