Local Tolerance for chemicals
Vivotecnia offers global REACH expertise and a comprehensive toxicology testing portfolio to support safety testing of chemicals according to information requirements detailed in annexes VII-X of the REACH directive for skin and eye irritation and skin sensitization testing. We can perform these tests for local tolerance for chemicals as stand-alone studies or as a part of an acute toxicity testing “six-pack”:
- Skin irritation / corrosion (in vitro / in vivo)
- Eye irritation / corrosion (in vitro / in vivo)
- Sensitization (in vitro / in vivo)
- Oral toxicity (OECD 423, 425, 420)
- Dermal toxicity (OECD 402)
- Acute inhalation toxicity (OECD 403, 436)
en blanco
Methodology
- REACH regulation (EC) No 1907/2006
- Directive 67/548/EEC and Regulation (EC) No 1272/2008 on the classification, labeling and packaging (CLP) of substances and mixtures
- Globally Harmonized System of Classification and Labeling of Chemicals (GHS)
Test Methods
- Acute eye irritation/corrosion, OECD 405
- Bovine corneal opacity and permeability test method for identifying i) chemicals inducing serious eye damage, and ii) chemicals not requiring classification for eye irritation or serious eye damage, OECD 437
- Short time exposure in vitro test method for identifying i) chemicals inducing serious eye damage, and ii) chemicals not requiring classification for eye irritation or serious eye damage, OECD 491
- Skin sensitization, OECD 406
- Skin sensitization – local lymph node assay, OECD 429
- Skin sensitization: local lymph node assay: DA, OECD 442A
- Skin sensitization: local lymph node assay: BrdU-ELISA or -FCM, OECD 442B
- In chemico skin sensitization: direct peptide reactivity assay (DPRA), OECD 442C
- In vitro skin sensitization: ARE-Nrf2 luciferase test method, OECD 442D