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Crop Care

At Vivotecnia, we help our clients develop crop care products in compliance with the requirements of European regulations EC No.1107/2009 and EC No. 284/2013.

To this end, we make available the in vitro and in vivo studies necessary to characterize your crop care product’s toxicological profile. All studies are carried out following the corresponding OECD guidelines and in strict compliance with good laboratory practices.

In vitro toxicity

  • Skin irritation: In vitro skin irritation: reconstructed human epidermis test method, OECD 439
  • Eye irritation: (EpiOcularTM) – Reconstructed human cornea-like epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage, OECD 492

In vivo acute toxicity:

In vivo short-term, repeated-dose toxicity (subacute or subchronic):

  • Repeated-dose 28-day oral toxicity study in rodents, OECD 407
  • Repeated-dose 90-day oral toxicity study in nonrodents, OECD 409
  • Repeated-dose dermal toxicity: 21/28-day study, OECD 410
  • Subchronic dermal toxicity: 90-day study, OECD 411
  • Repeated-dose 28-day inhalation toxicity study in rodents,
  • Subacute inhalation toxicity: 90-day study, OECD 413

Genotoxicity tests

Chronic toxicity and carcinogenesis tests:

Reproductive toxicity

  • Prenatal developmental toxicity study, OECD 414
  • One-generation reproduction toxicity study (rat or mouse), OECD 415
  • Two-generation reproduction toxicity study (rat), OECD 416
  • Reproduction/developmental toxicity screening test, OECD 421
  • Combined repeated-dose toxicity study with the reproduction/developmental toxicity screening test, OECD 422
  • Extended, one-generation reproductive toxicity study, OECD 443

Neurotoxicity studies

Other toxicological studies

  • Metabolite toxicity studies
  • Additional studies on active substances
  • Endocrine disruption properties



    For more information or a formal quotation, please send us a message and we will contact you as soon as possible.

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