Crop Care
At Vivotecnia, we help our clients develop crop care products in compliance with the requirements of European regulations EC No.1107/2009 and EC No. 284/2013.
To this end, we make available the in vitro and in vivo studies necessary to characterize your crop care product’s toxicological profile. All studies are carried out following the corresponding OECD guidelines and in strict compliance with good laboratory practices.
In vitro toxicity
- Skin irritation: In vitro skin irritation: reconstructed human epidermis test method, OECD 439
- Eye irritation: (EpiOcularTM) – Reconstructed human cornea-like epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage, OECD 492
- Acute dermal toxicity, OECD 402
- Acute dermal irritation/corrosion, OECD 404
- Acute eye irritation/corrosion, OECD 405
- Acute oral toxicity – fixed-dose procedure, OECD 420
- Acute oral toxicity – acute toxic class method, OECD 423
- Acute oral toxicity: up-and-down procedure, OECD 425
- Acute inhalation toxicity – acute toxic class method, OECD 436
In vivo short-term, repeated-dose toxicity (subacute or subchronic):
- Repeated-dose 28-day oral toxicity study in rodents, OECD 407
- Repeated-dose 90-day oral toxicity study in nonrodents, OECD 409
- Repeated-dose dermal toxicity: 21/28-day study, OECD 410
- Subchronic dermal toxicity: 90-day study, OECD 411
- Repeated-dose 28-day inhalation toxicity study in rodents,
- Subacute inhalation toxicity: 90-day study, OECD 413
Genotoxicity tests
- In vitro bacterial reverse mutation test (OECD 471, Ames test)
- In vitro mammalian chromosome aberration test, OECD 473
- Mammalian erythrocyte micronucleus test, OECD 474
- In vivo mammalian bone marrow chromosomal aberration test, OECD 475
- In vitro mammalian cell gene mutation test (mouse lymphoma assay, MLA), OECD 490
- In vivo studies with germ cells
- In vivo studies with somatic cells
Chronic toxicity and carcinogenesis tests:
- Carcinogenicity studies (rats or mice), OECD 451
- Chronic toxicity study (rodents, 12 months), OECD 452
- Combined chronic toxicity/carcinogenicity studies, OECD 453
Reproductive toxicity
- Prenatal developmental toxicity study, OECD 414
- One-generation reproduction toxicity study (rat or mouse), OECD 415
- Two-generation reproduction toxicity study (rat), OECD 416
- Reproduction/developmental toxicity screening test, OECD 421
- Combined repeated-dose toxicity study with the reproduction/developmental toxicity screening test, OECD 422
- Extended, one-generation reproductive toxicity study, OECD 443
Neurotoxicity studies
- Neurotoxicity study in rodents, OECD 424
Other toxicological studies
- Metabolite toxicity studies
- Additional studies on active substances
- Endocrine disruption properties