Inhalation Experience

Vivotecnia offers its extensive experience in inhalation toxicology and efficacy studies for rodent and nonrodent species. Our state-of-the-art facility run by our inhalation experts ensures top-quality studies and our team accompanies customers throughout the study process. We perform inhalation tests ranging from acute to chronic exposure, all according to OECD and ICH guidelines and under GLP for chemical (REACH), medicinal, phytosanitary and feed additive products. We also offer custom-designed studies to meet your specific requirements.

Moreover, Vivotecnia offers you the possibility to conduct tobacco inhalation studies with standard cigarettes, e-cigarettes or heat-not-burn cigarettes.

Our experience includes:

Chemical studies:

• Acute inhalation toxicity (rats), OECD 403
• Acute inhalation toxicity – acute toxic class method (rats), OECD 436
• Subacute inhalation toxicity: 28-day study (rats), OECD 412
• Subchronic inhalation toxicity: 90-day study (rats), OECD 413
• Prenatal developmental toxicity study (rats), OECD 414

Feed additive studies:

• Acute inhalation toxicity – acute toxic class method (rats), OECD 436

Nanomaterial studies:

• Toxicity of multi-walled carbon nanotube aerosol after repeated administration through nose-only inhalation route

Tobacco studies:

• Biological activity of mainstream smoke from reference cigarettes on nose-only inhalation study in rats (standard cigarettes)
• Smoking of a prototype of electronic cigarette (e-cigarette): nose-only exposure study in rats
• Smoking of a heat-not-burn cigarette: nose-only exposure study in rats
• Pharmacokinetic profile of nicotine after nose-only inhalation exposure of rats to smoke from a smoking device