acute inhalation toxicity

Acute inhalation toxicity

Acute inhalation toxicity is the result of the adverse effects caused by substances after a single uninterrupted exposure by inhalation over a short period of time of 24 hours or less to a substance capable of being inhaled.

A fixed duration exposure of 4 hours is generally recommended, but shorter or longer exposure durations may be appropriate to meet specific objectives. Vivotecnia inhalation team will advise you on the recommended exposure according to the substance and the objectives that are determined in the study.

This test provides information on the hazardous proprieties and allows the classification of the test items according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS). In principle, the test is not intended for the calculation of a precise LC50, but does give a valuable indication for the determination of defined exposure ranges where lethality is expected since death of a proportion of the animals is still the major endpoint of the acute toxicity studies. It will enable a judgment with respect to classifying the test item to one of a series of toxicity classes defined by fixed LC50 cut-off values.

Vivotecnia inhalation toxicology facilities are authorized to carry out experimental animal exposition studies under the good laboratory practices. You can know more about our inhalation facilities, please click here

  • Flow-past chambers can accommodate up to 56 animals and 8 sampling points
  • Facilities endowed with 12 inhalation chambers
  • Separated control room

 

 

  • Different concentration
  • Monitored gravimetrically and analytically
  • Vapour, liquid and dust inhalation
  • Rodents
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Our team and Experience

Vivotecnia has some of the most experienced, most talented minds in the industry, working closely with our clients while remaining flexible and responsive to find solutions to your needs. The extensive experience of our team of scientist represent a wide range of disciplines and all of them are fully committed to your non-clinical development program. Their extensive experience with complex general toxicology studies and their ability to respond to unexpected issues, enable you to achieve robust and regulatory compliant data, keeping you moving forward with your registration process.



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