Inhalation Methodology

Inhalation Toxicology for Testing Chemicals:

• Acute inhalation toxicity – acute toxic class method, OECD 436
• Acute inhalation toxicity, OECD 403 and Acute inhalation toxicity, EPA OPPTS 870.1300
• Subacute inhalation toxicity: 28-day study, OECD 412
• Subchronic inhalation toxicity: 90-day study, OECD 413 and 90-day inhalation toxicity, OPPTS 870.3465
• Guidance document on acute inhalation toxicity testing, OECD ENV/JM/MONO(2009)28

Inhalation Toxicity for Testing Tobacco:

• Cigarettes – Determination of total and nicotine-free dry particulate matter using a routine analytical smoking machine, ISO 4387:2000
• ISO and Health Canada intense smoking parameters – Part 1: Results of an international machine smoking study, ISO/TR 19478-1:2014
• ISO and Health Canada intense smoking parameters – Part 2: Examination of factors contributing to variability in the routine measurement of TPM, water and NFDPM smoke yields of cigarettes, ISO/TR 19478-2:2015
• Routine analytical cigarette-smoking machine – Definitions and standard conditions, ISO 3308:2012
• Standard Operating Procedure for Intense Smoking of Cigarettes, WHO (World Health Organization)
• Tobacco and tobacco products – Atmosphere for conditioning and testing, ISO 3402:1999