inhalation

Inhalation Team

Inhalation team includes both highly qualified senior study director and technicians with wide expertise in the following areas:

  • Set-up exposure system
  • Characterisation of test atmosphere: test concentration and particle size distribution.
  • Atmosphere monitoring: air flow rate, temperature, relative humidity, oxygen and CO2
  • Aerosol generation: solid, liquid and vapour products
  • Smoke aerosol generation. Several types of smoking machines: ISO and Canadian Intense regimen.
  • Detailed clinical observations in rodents based in respiratory pattern or behaviour as well as changes in posture and response to handling and the presence of abnormal movements.
  • Collection and analysis of bronchoalveolar lavage fluid (BALF)
  • Histophatology of respiratory tract organs:
Histological sections of respiratory tract organs
OrganSection
Nose (4 transverse sections)immediately posterior to the upper incisor teeth
posterior to incisive papilla
at second palatal ridge
between first and second molar teeth
Larynx (4 transverse sections)at mid base of epiglottis level 0 (below)
at distal base of epiglottis level 1 (below)
at arytenoids projections level 2 (below)
at vocal folds level 4 (below)
Trachea (1 longitudinal section)at bifurcation
Lungs (1 longitudinal section)all lobes

 

  • In situ plethysmography during the exposure.
  • Analytical and bioanalytical determination with HPLC and gas cromatography.
  • Blood carboxyhemoglobin determination
inhalation team


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