
Pharmacokinetics
Animal models: rodent (mice, rat, hamster, guinea pig) and non-rodent (rabbit, dog, minipig, NHP).
Dosing routes:
- Oral: gavage, capsules, pills
- Intravenous
- Subcutaneous
- Dermal
- Intra-dermal
- Intramuscular
- Intraperitoneal
- Intra-nasal
- Intra-vaginal
- Intra-rectal
- Ocular
- Advanced bioanalytical method development
- Method transfer
- Method qualification pharmacokinetics (PK) services
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Our team and experience
Our expert team and strategic partners are well versed in GLP regulations and by using only the state-of-the-art instrumentation and the most up-to-date methods, together we can perform studies with significant cost savings to clients. Our pharmacokinetic and metabolism scientists can provide the following services, to characterize the absorption, distribution, metabolism, and excretion (ADME) profiles of your compound:
- In vivo Pharmacokinetics/toxicokinetics
- Bioanalytical methods development and validation
Methodology
Pharmacokinetic/toxicokinetic studies
- Note for guidance on toxicokinetics: the assessment of systemic exposure in toxicity studies, ICH S3A, October 1994
- Pharmacokinetics: guidance for repeated dose tissue distribution studies, ICH S3B, October 1994
- Guideline on the evaluation of control samples for non-clinical safety studies: checking for contamination with the test substance, EMA/CPMP/SWP/1094/04, March 2005
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