pharmacokinetics

Pharmacokinetics

Animal models: Rodent (Mice, Rat, Hamster, Guinea Pig) and non-rodent (rabbit, dog, minipig, NHP).

Dosing routes:

  • Oral: gavage, capsules, pills
  • Intravenous
  • Subcutaneous
  • Dermal
  • Intra-dermal
  • IntrAmuscular
  • Intraperitoneal
  • Intra-nasal
  • Intra-vaginal
  • Intra-rectal
  • Ocular
  • Advanced Bioanalytical Method Development
  • Method Tranfer
  • Method Qualification Pharmacokinetics (PK)Services
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Our team and Experience
Vivotecnia can provide advice and respond to your needs regarding the whole range of preclinical pharmacokinetic and metabolism studies available, which can be offered either as a stand-alone service or as an integrated offer.

Our experienced team and strategic partnerships are highly trained in GLP regulations and using only the state-of-the-art instrumentations and most updated methods to conduct studies with significant cost savings to clients. Our pharmacokinetic and metabolism scientist can provide the following services, for the characterization of absorption, distribution, metabolism, and excretion (ADME) profiles of your compound:

  • In vivo Pharmacokinetics/Toxicokinetics
  • Bioanalytical methods development and validation
Methodology
  • Pharmacokinetics/Toxicokinetics Studies
    • ICH S3A; finalised (Step 4) October 1994 Note for Guidance on Toxicokinetics: The Assessment of Systemic Exposure in Toxicology Studies.
    • ICH S3B Pharmacokinetics: repeated dose tissue distribution studies.
    • CPMP/SWP/1094/04; adopted March 2005. Committee for Human Medicinal Products: Guideline on the Evaluation of Control Samples for Non-Clinical Safety Studies: Checking for Contamination with the Test Substance.

For more information or a formal request, please send us a message and we will contact you as soon as possible:



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