Acute inhalation toxicity

Fixed-duration exposure of four hours is generally recommended for testing, but shorter or longer exposure times may be appropriate to meet specific objectives. Vivotecnia’s inhalation team will advise you on the recommended exposure depending on the substance and the objectives that are established for the study.

Acute inhalation toxicity testing provides information on a test item’s hazardous properties and permits its classification according to the globally harmonized system of classification and labelling of chemicals (GHS). In principle, the test is not intended to calculate a precise LC₅₀ but does give a valuable indication to determine defined exposure ranges where lethality is expected, as death of a proportion of the animals is still the principal endpoint for the acute toxicity studies. As such, acute inhalation toxicity testing will permit an informed judgment to be made regarding the test item’s assignment to one of a series of toxicity classes defined by fixed LC₅₀ cut-off values.

Vivotecnia’s inhalation toxicology facilities are authorized to carry out experimental animal exposure studies under good laboratory practices. To learn more about our inhalation facilities, please click here