Inhalation
At Vivotecnia, we have extensive experience in inhalation toxicology and efficacy studies in both rodent and non-rodent species, supported by fully integrated, proprietary inhalation technology operated in-house. We are the only CRO worldwide offering this level of dedicated inhalation capability, enabling precise, reproducible and regulatory-compliant studies tailored to the specific properties of each compound and the most demanding international standards.
Preclinical regulatory CRO
Established – 2000
All inhalation studies are conducted in our dedicated, cutting-edge inhalation facility, operated exclusively by a specialized team of inhalation scientists and technicians. Unlike conventional CROs that rely on external systems or standard equipment, Vivotecnia designs, operates and controls its own inhalation exposure technologies, ensuring full oversight of study execution and data quality.
Our facilities and processes ensure full compliance with Good Laboratory Practices (GLP) and the most demanding international standards (OECD, ICH). We operate 7 days a week, 365 days a year, providing unmatched continuity, flexibility and reliability for complex inhalation projects.
At Vivotecnia, we tailor the generation of respirable test atmospheres to the physical characteristics of each compound, ensuring controlled, reproducible, and regulatory-compliant exposure conditions.
Homogeneus mixtures are produced using dynamic dilution systems, enabling highly accurate and traceable control of target concentrations.
Volatile substances and inhalable liquid formulations are transformed into vapors of fine aerosols through advanced nebulization techniques.
Dry powders are aerosolized using high-performance dust generators, producing particles within the respirable range (1-5 μm).
Vivotecnia is the only CRO worldwide equipped with proprietary, custom-designed glass exposure tubes for inhalation studies. This exclusive technology represents a true benchmark in inhalation toxicology and is a key differentiator of our CRO capabilities. These tubes:
This system enables precise and reproducible inhalation exposure – a technological benchmark in the field.
Our infrastructure allows different inhalation study setups adapted to compound type and regulatory needs:
Our animal facilities are equipped with specialized housing that meets and exceeds European welfare standards. We apply an active enrichment program tailored to each species.
Acute inhalation toxicity – Acute toxic class method
Acute inhalation toxicity – Fixed concentration procedure
Subacute inhalation toxicity – 28-day study
Subchronic inhalation toxicity – 90-day study
In addition, we design fully customized inhalation studies for compounds with special requirements, novel formulations or complex formats, including aerosols, gases, vapors, nanoparticles and solid particles.
We apply rigorous protocols to safeguard Vivotecnia personnel during all inhalation studies. Our directed airflow systems and isolated chambers minimize exposure risks while ensuring full environmental stability.
Biotechnology
Chemical
Inhaled Products & Respiratory Therapies
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