Inhalation toxicity studies are required to assess the exposure hazards for consumer products or manufacturing workers.
In accordance with the requeriments of OECD guidelines for testing of chemicals, inhalation studies are designed “to satisfy hazard classification and labeling requirements, to estimate the toxicity of mixtures, and to assess human health and environmental risk”. “Acute inhalation toxicity studies can also charactize hazards associated with end-user produts (e.g. biocides used indoors, multipurpose spray cans, aerosolized cleansing agents, incense to repel insects)”.
“Repeated exposure inhalation toxicity data are used to satisfy hazard characterization requirements with focus on a NOAEL”. “Therefore, in these types of studies, the primary focus is not on the classification and labeling of substances/mixtures as being commercialized but rather on characterization of toxic mechanisms and exposure atmospheres causing health hazards to repeatedly exposed humans”.
Our services ensure the compliance with OECD guidelines for acute inhalation as well as repeated administration through inhalation route.
In addition, inhalation route is an active area for pharmaceuticals drug development. Therefore, inhalation toxicity studies are aimed at potential inhaled therapeutics products.
Tobacco inhalation studies:
Tobacco inhalation studies are design to assess the toxicological effects of mainstream smoke (standard cigarettes) or smoke aerosol (e-cigarettes and heat-not-burn cigarettes).
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