Genotoxicity Testing
At Vivotecnia, we conduct the In Vivo Micronucleus Test (OECD TG 474) to assess the potencial of a substance to cause chromosomal damage in living organism. This assay detects micronuclei in erythrocytes of bone marrow or peripheral blood in rodents, providing essential information about genotoxicity in a systemic biological context.
Preclinical regulatory CRO
Established – 2000
The In Vivo Micronucleus Test is required by major regulatory agencies (EMA, FDA, OECD) as a key in vivo assay to confirm or refute positive findings from in vitro tests. It form part of the ICH S2(R1) strategy and supports the evaluation of both clastogenic and aneugenic effects of chemical compounds.
Chemical
Food
Vivotecnia has a highly specialized bioanalytical unit that combines state-of-the-art technology with a multidisciplinary team of experts in regulated preclinical studies.
SCIEX Triple Quad™ LC-MS/MS, UPLC, HPLC, NanoLC 400 and robotic automation systems for sample handling.
Provantis® platform for document control, traceability and regulatory compliance.
Professionals with experience in more than 4,000 preclinical studies, including mutagenicity, toxicity and pharmacokinetics.
All assays are performed under GLP certification and are audited by our internal Quality Assurance unit.
Need to include an In Vivo Micronucleus
Test in you regulatoy study package?
Let our expert team guide you though a
compliant and efficient study process.
