Genotoxicity Testing
At Vivotecnia we perform the In Vitro Mammalian Chromosome Aberration Test (OECD TG 473) as part of our standarized genotoxicity test battery. This assay evaluates the ability of chemical compounds to induce structural chromosomal damage in cultured mammalian cells, providing crucial information for early preclinical risk assessment.
Preclinical regulatory CRO
Established – 2000
The Chromosome Aberration Test is required by international regulatory agencies such as the EMA, FDA and OECD for the safety assessment of pharmaceuticals, industrial chemicals, cosmetic products and food additives. It is a core component of the ICH S2(R1) guidelines and is essential in determining a substance’s clastogenic potencial before moving to in vivo testing.
Chemical
Food
Vivotecnia has a highly specialized bioanalytical unit that combines state-of-the-art technology with a multidisciplinary team of experts in regulated preclinical studies.
SCIEX Triple Quad™ LC-MS/MS, UPLC, HPLC, NanoLC 400 and robotic automation systems for sample handling.
Provantis® platform for document control, traceability and regulatory compliance.
Professionals with experience in more than 4,000 preclinical studies, including mutagenicity, toxicity and pharmacokinetics.
All assays are performed under GLP certification and are audited by our internal Quality Assurance unit.
Do you need to perform a Chromosome
Aberration Test as part of your regulatory
dossier? Our team is ready to asist you
with a fully compliant study!
