General Toxicology Testing
At Vivotecnia, we conduct Dose Range Finding (DRF) and Maximum Tolerated Dose (MTD) studies as key preliminary steps in the design of regulatory toxicology programs. There exploratory, non-GLP studies help determine the appropriate dose levels and identify early signs of toxicity, allowing for safe and effective planning of subsequent GLP-compliant studies.
Preclinical regulatory CRO
Established – 2000
DRF and MTD studies are critical for identifying potential target organs, clinical signs, and systemic exposure ranges before initiating repeated dose studies. Although these studies are not intended for regulatory submission, they play an essencial role in defining dose levels for 28- or 90- day GLP toxicology studies, evaluating compound tolerability and early toxicity signals, assessing gender-related differences in responde and refining the study design to avoid unnecessary animal use.
Chemical
Food
Vivotecnia has a highly specialized bioanalytical unit that combines state-of-the-art technology with a multidisciplinary team of experts in regulated preclinical studies.
We have conducted hundreds of DRF and MTD studies to support toxicology packages for pharmaceutical, chemical, cosmetic and food industry clients.
Even for non-GLP studies, our infrastructure ensures full environmental control and traceability.
Our DMF/MTD studies are seamlessly integrated with GLP-compliant studies, reducing time and optimizing resources.
We apply the 3Rs to minimize animal use while ensuring robust and informative study designs.
Need to determine the right dose levels
before starting your GLP study?
Our team is ready to help you define a
safe and effective toxicology plan.
