General Toxicology Testing

Repeated dose studies

Repeated Dose Studies are a cornerstone of preclinical safety assessment. At Vivotecnia, we offer GLP-compliant subacute, subchronic and chronic toxicity studies to evaluate the effects of repeated exposure to a test item over time. These studies are essential to determine the No Observed Adverse Effect Level (NOAEL) and are required for regulatory submissions across pharmaceutical, chemical, cosmetic and food sectors. 

Preclinical regulatory CRO

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Assessing safety through time

Repeated dose toxicity studies provide a detailed picture of how a compound behaves in the body under continuous exposure. They help to identify the evolution of potential systemic toxicity, support NOAEL determination, identification of dose-response relationships, histophysiological analysis of key organs and are mandatory for most regulatory toxicology packages.

TYPICAL STUDY ENDPOINT

What we offer at Vivotecnia

GLP and Non-GLP certified exploratory studies adapted to your compound

OECD guideline-compliant protocols (e.g. 407, 408, 409)

Study durations: 14, 28, 90 or 180 days

Satellite groups for toxicokinetics or reversibility evaluation

Full histopathology and clinical pathology analysis

Industries we support

Pharmaceutical
Pharmaceutical
Chemical 

Chemical 

Cosmetics 

Food

Food & Nutrition 
Food & Nutrition 

Infrastructure and equipment

Vivotecnia has a highly specialized bioanalytical unit that combines state-of-the-art technology with a multidisciplinary team of experts in regulated preclinical studies.

Infrastructure and equipment

WHY VIVOTECNIA

Expert team

Experienced team

We have conducted hundreds of DRF and MTD studies to support toxicology packages for pharmaceutical, chemical, cosmetic and food industry clients.

Excellence in quality and compliance 

GLP-certified facilities

Even for non-GLP studies, our infrastructure ensures full environmental control and traceability. 

Integrated approach

Integrated approach

Our DMF/MTD studies are seamlessly integrated with GLP-compliant studies, reducing time and optimizing resources.

Committed to animal welfare and sustainability

Animal welfare commitment

We apply the 3Rs to minimize animal use while ensuring robust and informative study designs.

Need to assess the long-term safety of
your compound? Let our team design and
conduct. Fully compliant repeated dose
study for your next development
milestone.

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