The in vivo nude mouse xenograft model is a useful tool to investigate the events involved in cell malignant transformation, invasion and metastasis, as well as to evaluate the efficacy and/or mechanisms underlying therapeutic approaches. Vivotecnia hold a range of cell lines from breast, colorectal, brain, connective tissue, lung, skin, bone, pancreas and muscle available for establishment (cell dose/animal, vehicle, volume of administration etc to define the tumour volume growth post-cell inoculation).
Additional efficacy models available include:
- Inflammation (collagen induced arthritis model)
- Diabetes (streptozotocin-induced diabetes model)
- Sepsis (Lipopolysaccharide-induced sepsis model)
We are experienced in developing new efficacy models. We will be pleased to evaluate how we can help you in your research project.
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Our in-house team of veterinarians ensure that animal welfare is paramount and are committed to the principals of the 3Rs (refinement, reduction, replacement)
Our team of experienced, highly-educated scientists, with backgrounds in toxicology, molecular biology, chemistry and immunology, understand that the drug development process is no longer a one-size fits all approach.