efficacy models

Efficacy models

The in vivo nude mouse xenograft model is a useful tool to investigate the events involved in cell malignant transformation, invasion and metastasis, as well as to evaluate the efficacy and/or mechanisms underlying therapeutic approaches. Vivotecnia hold a range of cell lines from breast, colorectal, brain, connective tissue, lung, skin, bone, pancreas and muscle available for establishment (cell dose/animal, vehicle, volume of administration etc to define the tumour volume growth post-cell inoculation).

Tumoral cell lines

Additional efficacy models available include:

  • Inflammation (collagen induced arthritis model)
  • Diabetes (streptozotocin-induced diabetes model)
  • Sepsis (Lipopolysaccharide-induced sepsis model)

We are experienced in developing new efficacy models. We will be pleased to evaluate how we can help you in your research project.

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PK/PD and Metabolism

Over the drug discovery process, ADME (Absorption, Distribution, Metabolism, and Elimination) and PK studies are deemed necessary to evaluate the bioavailability…

inhalation services

Inhalation

Inhalation toxicity studies are required to assess the exposure hazards for consumer products or manufacturing workers.

Non-human Primates

Our in-house team of veterinarians ensure that animal welfare is paramount and are committed to the principals of the 3Rs (refinement, reduction, replacement)

General Toxicology

Our team of experienced, highly-educated scientists, with backgrounds in toxicology, molecular biology, chemistry and immunology, understand that the drug development process is no longer a one-size fits all approach.

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