The in vivo nude mouse xenograft model is a useful tool to investigate the events involved in malignant cell transformation, invasion and metastasis, as well as to evaluate the efficacy and/or mechanisms underlying therapeutic approaches. Vivotecnia would also be pleased to set up an efficacy model for you from the many cell lines (breast, colorectal, brain, connective tissue, lung, skin, bone, pancreas and muscle) that we hold. We can help you determine the cell dose/animal, vehicle, volume of administration etc. to define the tumor volume growth post-cell inoculation.
Additional efficacy models available include:
- Inflammation (collagen induced arthritis model)
- Diabetes (streptozotocin-induced diabetes model)
- Sepsis (lipopolysaccharide-induced sepsis model)
We are experienced in developing new efficacy models and would be pleased to evaluate how we can assist you in your research project.
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PK/PD and Metabolism
During the drug discovery process, ADME (absorption, distribution, metabolism, and excretion) and PK studies are deemed necessary to evaluate bioavailability.
Inhalation toxicity studies are required to assess the exposure hazards of consumer products or to manufacturing workers
Our in-house team of veterinarians ensures that animal welfare is paramount and is fully committed to the principles of the 3Rs (replacement, reduction, refinement)
Our team of experienced, highly-educated scientists, experts in toxicology, molecular biology, chemistry and immunology, fully understands that the drug development process is distinct for each approach