Vivotecnia offers Irwin test as central nervous system study, which is included in our safety pharmacology services portfolio. The Irwin test enables us to assess the general effects of a test substance on central nervous system activity and physiological functions. With this test the following parameters can be estimated:
- The minimum lethal dose of a test substance
- The dose range for CNS responses
- The primary effects on behavior and physiological functions
The results of Irwin test are used to predict potential therapeutic activity and to select doses for subsequent tests of efficacy. In addition, these data are also used to assess the risks associated with the use of a drug candidate in safety pharmacology studies.
Procedure Irwin test
Rats or mice are administered the test substance and then observed for the next several hours and on the next day. Signs will be grouped into several categories in an attempt to highlight the particular characteristics of the test substance, as follows:
Would you like to know more about Irwin test?, We present you the behaviors and clinical signals observed in Irwin test after Morphine and diazepam administration. Please click
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Loss of grasping
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