The 2001 European Commission proposal for the Registration, Evaluation and Authorisation of Chemicals REACH) aims to improve public and environmental health by assessing the toxicity of, and restricting exposure to, potentially toxic chemicals. The requirements for carcinogenicity testing of Industrial Chemicals, regulated by REACH, are based on a tiered approach according to which, , a two-year carcinogenicity assay may be required for certain chemicals produced at >1000 metric tonnes per year. In addition, some chemicals that are found to be genotoxic will also require testing.
Our team and Experience
Our team includes both highly qualified senior study director and technicians with wide expertise in the following areas.
The performance of carcinogenicity studies requires an extensive knowledge of the spontaneous frequency of certain pathological changes, since it may be substantial differences between species and strains. Our carcinogeniticy group is skilled at performing histopathological assessments in rodent carcinogenicity studies, applying standard diagnostic criteria across the large numbers of tissues examined following RITA (Registry of Industrial Toxicology Animal-data) standards. In addition to standard staining methodology, special preparations may be included to further characterize lesions seen in the tissues.
Carcinogenicity studies for Chemicals
Maybe you are interested in…
Our team of experienced, highly-educated scientists, with backgrounds in toxicology, molecular biology, chemistry and immunology, understand that the drug development process is no longer a one-size fits all approach.
Inhalation toxicity studies are required to assess the exposure hazards for consumer products or manufacturing workers.
Our in-house team of veterinarians ensure that animal welfare is paramount and are committed to the principals of the 3Rs (refinement, reduction, replacement)