Carcinogenicity team

Carcinogenicity

Chemical carcinogens are substances or mixtures which have the potential to induce cancer in humans under certain conditions or after prolonged or excessive periods of exposure. Chemical carcinogens can be natural chemicals, synthetic compounds or mixtures of both, which are produced or used for industrial, agricultural or commercial purposes.

The 2001 European Commission proposal for the registration, evaluation, and authorization of chemicals (REACH) aims to protect public and environmental health by assessing the toxicity of, and restricting exposure to, potentially toxic chemicals. The requirements for carcinogenicity testing of industrial chemicals, regulated by REACH, are based on a tiered approach according to which, a two-year carcinogenicity assay may be required for certain chemicals marketed at more than 1000 metric tons per year. Additionally, some chemicals that are found to be genotoxic will also require carcinogenicity testing.

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Our team and experience

Our team includes both highly qualified senior study directors and technicians with broad expertise in the areas described below.

To conduct carcinogenicity studies requires an in-depth knowledge of the spontaneous frequency of certain pathological changes, as there may be substantial differences between species and strains. Our carcinogenicity group is skilled at performing histopathological assessments in rodent carcinogenicity studies, applying standard diagnostic criteria across the large numbers of tissues examined following RITA (Registry of Industrial Toxicology Animal-data) standards. Special preparations may be included in addition to standard staining methodology to further characterize any observed tissue lesions

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