Carcinogenicity team


Chemical carcinogens are substances or mixtures which have the potential to induce cancer to humans under certain conditions and for prolonged or excessive periods of exposure. Chemical carcinogens can be natural chemicals, synthetic compounds or mixtures of both, that are produced or used for industrial, agricultural or commercial purposes.
The 2001 European Commission proposal for the Registration, Evaluation, and Authorisation of Chemicals REACH) aims to improve public and environmental health by assessing the toxicity of, and restricting exposure to, potentially toxic chemicals. The requirements for carcinogenicity testing of Industrial Chemicals, regulated by REACH, are based on a tiered approach according to which, a two-year carcinogenicity assay may be required for certain chemicals produced at >1000 metric tonnes per year. In addition, some chemicals that are found to be genotoxic will also require testing.

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Our team and Experience



Our team includes both highly qualified senior study director and technicians with wide expertise in the following areas.

The performance of carcinogenicity studies requires extensive knowledge of the spontaneous frequency of certain pathological changes, since it may be substantial differences between species and strains. Our carcinogenicity group is skilled at performing histopathological assessments in rodent carcinogenicity studies, applying standard diagnostic criteria across the large numbers of tissues examined following RITA (Registry of Industrial Toxicology Animal-data) standards.  In addition to standard staining methodology, special preparations may be included to further characterize lesions seen in the tissues.


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