Six Pack Toxicology

Vivotecnia offers in vivo acute toxicology testing together with in vitro toxicology studies in order to meet regulatory requirements for acute toxicity testing.

This battery of tests will provide information on health hazards likely to arise from a short-term exposure to a test substance by different routes administration.

Each test is designed to perform a limit test or it can define the concentration of your product.

Oral toxicity

• OECD 420 Acute oral toxicity-fixed dose procedure.
• OECD 423 Acute oral toxicity-acute toxic class method.
• OECD 425 Acute oral toxicity: u-and-down procedure.

Inhalation acute toxicity

• OECD 403 Acute inhalation toxicity
• OECD 433 Fixed concentration procedure
• OECD 436 Acute inhalation toxicity: acute toxic class method

Dermal toxicity

• OECD 402 Acute dermal toxicity

Skin irritation/corrosion

• OECD 431: In Vitro Skin Corrosion: Human Skin Model Test.
• OECD 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method
• OECD 404: Acute Dermal Irritation/Corrosion (In vivo)

Skin sensitization

• OECD 442b: Skin sensitization
• OECD 429: Skin Sensitisation Local Lymph Node Assay
• OECD 442d: In Vitro Skin Sensitisation ARE-Nrf2 Luciferase Test Method

Eye irritation/corrosion

• OECD 491: Short Time Exposure In Vitro Test
• OECD 437: Bovine Corneal Opacity and Permeability Test Method
• OECD 405: Acute Eye Irritation/Corrosion.